An XBox version was planned, but ultimately cancelled due to the low sales of the game.
Jimmy has an assignment to write a book report, and Jimmy decides to invent the Virtual World Reproduction Machine (VWRM), a device that will show the class what the book is about like a movie. Jimmy places his Jet Fusion book into the machine and it malfunctions, thus turning Retroville into a virtual world. Then, Professor Calamitous kidnaps Jet Fusion and it's up to Jimmy to save him.
In the game, the player controls Jimmy Neutron who has to save the movie star/spy Jet Fusion by using a variety of gadgets and inventions.
Throughout the game, the player has to collect pieces for major and minor inventions, which help Jimmy continue to the next level. The one major invention in each level helps defeat the boss in the boss level, while the one minor invention in each world helps Jimmy battle his enemies and various obstacles. The minor inventions also come with a primary and secondary action.
While being a video game based loosely on the show, a lot of new/original characters were made exclusively for the game.